- Hematology
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Characteristics and Clinical Outcomes of Critically Ill Cancer Patients Admitted to Korean Intensive Care Units
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Soo Jin Na, Tae Sun Ha, Younsuck Koh, Gee Young Suh, Shin Ok Koh, Chae-Man Lim, Won-Il Choi, Young-Joo Lee, Seok Chan Kim, Gyu Rak Chon, Je Hyeong Kim, Jae Yeol Kim, Jaemin Lim, Sunghoon Park, Ho Cheol Kim, Jin Hwa Lee, Ji Hyun Lee, Jisook Park, Juhee Cho, Kyeongman Jeon
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Acute Crit Care. 2018;33(3):121-129. Published online August 31, 2018
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DOI: https://doi.org/10.4266/acc.2018.00143
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Abstract
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- Background
The objective of this study was to investigate the characteristics and clinical outcomes of critically ill cancer patients admitted to intensive care units (ICUs) in Korea.
Methods This was a retrospective cohort study that analyzed prospective collected data from the Validation of Simplified Acute Physiology Score 3 (SAPS3) in Korean ICU (VSKI) study, which is a nationwide, multicenter, and prospective study that considered 5,063 patients from 22 ICUs in Korea over a period of 7 months. Among them, patients older than 18 years of age who were diagnosed with solid or hematologic malignancies prior to admission to the ICU were included in the present study.
Results During the study period, a total of 1,762 cancer patients were admitted to the ICUs and 833 of them were deemed eligible for analysis. Six hundred fifty-eight (79%) had solid tumors and 175 (21%) had hematologic malignancies, respectively. Respiratory problems (30.1%) was the most common reason leading to ICU admission. Patients with hematologic malignancies had higher Sequential Organ Failure Assessment (12 vs. 8, P<0.001) and SAPS3 (71 vs. 69, P<0.001) values and were more likely to be associated with chemotherapy, steroid therapy, and immunocompromised status versus patients with solid tumors. The use of inotropes/ vasopressors, mechanical ventilation, and/or continuous renal replacement therapy was more frequently required in hematologic malignancy patients. Mortality rates in the ICU (41.7% vs. 24.6%, P<0.001) and hospital (53.1% vs. 38.6%, P=0.002) were higher in hematologic malignancy patients than in solid tumor patients.
Conclusions Cancer patients accounted for one-third of all patients admitted to the studied ICUs in Korea. Clinical characteristics were different according to the type of malignancy. Patients with hematologic malignancies had a worse prognosis than did patients with solid tumor.
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Citations
Citations to this article as recorded by
- Outcomes of Acute Respiratory Failure in Patients With Cancer in the United States
Kiyan Heybati, Jiawen Deng, Archis Bhandarkar, Fangwen Zhou, Cameron Zamanian, Namrata Arya, Mohamad Bydon, Philippe R. Bauer, Ognjen Gajic, Allan J. Walkey, Hemang Yadav Mayo Clinic Proceedings.2024; 99(4): 578. CrossRef - Characteristics and outcomes of cancer patients admitted to intensive care units in cancer specialized hospitals in China
Wensheng Liu, Dongmin Zhou, Li Zhang, Mingguang Huang, Rongxi Quan, Rui Xia, Yong Ye, Guoxing Zhang, Zhuping Shen Journal of Cancer Research and Clinical Oncology.2024;[Epub] CrossRef - Predictors of ICU mortality in patients with hemoblastosis and infectious complications
A.V. Lyanguzov, A.S. Luchinin, S.V. Ignatyev, I.V. Paramonov Anesteziologiya i reanimatologiya.2023; (1): 33. CrossRef - Effect of the underlying malignancy on critically ill septic patient's outcome
Man‐Yee Man, Hoi‐Ping Shum, Sin‐Man Lam, Jacky Li, Wing‐Wa Yan, Mei‐Wan Yeung Asia-Pacific Journal of Clinical Oncology.2022; 18(4): 473. CrossRef - Impacts of Corticosteroid Therapy at Acute Stage of Hospital-Onset Clostridioides difficile Infections
Ching-Chi Lee, Jen-Chieh Lee, Chun-Wei Chiu, Pei-Jane Tsai, Wen-Chien Ko, Yuan-Pin Hung Infection and Drug Resistance.2022; Volume 15: 5387. CrossRef - Hospital mortality and prognostic factors in critically ill patients with acute kidney injury and cancer undergoing continuous renal replacement therapy
Da Woon Kim, Geum Suk Jang, Kyoung Suk Jung, Hyuk Jae Jung, Hyo Jin Kim, Harin Rhee, Eun Young Seong, Sang Heon Song Kidney Research and Clinical Practice.2022; 41(6): 717. CrossRef - A Systematic Review and Meta-Analysis Evaluating Geographical Variation in Outcomes of Cancer Patients Treated in ICUs
Lama H. Nazer, Maria A. Lopez-Olivo, Anne Rain Brown, John A. Cuenca, Michael Sirimaturos, Khader Habash, Nada AlQadheeb, Heather May, Victoria Milano, Amy Taylor, Joseph L. Nates Critical Care Explorations.2022; 4(9): e0757. CrossRef - Clinico-demographic and Outcome Predictors in Solid Tumor Patients with Unplanned Intensive Care Unit Admissions: An Observational Study
Jigeeshu Divatia, Amit M Narkhede, Harish K Chaudhari, Ujwal Dhundi, Natesh Prabu Ravisankar, Satish Sarode Indian Journal of Critical Care Medicine.2021; 25(12): 1421. CrossRef
- Cardiology
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Life-Threatening Acute Fulminant Myocarditis Following a Coffee Diet Program
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Jung Hyun Kim, Hee Kyung Kim, Kyu Hyun Han, Bo Hye Kim, Hak Su Kim, Sun Young Shin, Eun Kyung Kim, Hye Cheol Jeong, Ji Hyun Lee
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Korean J Crit Care Med. 2014;29(2):119-122. Published online May 31, 2014
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DOI: https://doi.org/10.4266/kjccm.2014.29.2.119
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Abstract
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- Myocarditis is an inflammatory disease of the myocardium caused by various infectious or noninfectious triggers.
Although viral infections are important causes of myocarditis, some drugs or toxins can also cause myocarditis. We report a case of life-threatening fulminant myocarditis which followed an extensive coffee diet program.
Despite medical treatment, the patient was not able to maintain hemodynamic stability. She was supported by extracorporeal membrane oxygenation and completely recovered 3 months later.
- Cardiology
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Successful Use of a Peripheral Extracorporeal Membrane Oxygenator in a Patient with Chronic Heart Failure and Pneumonia
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Ji Hyun Lee, Yang Hyun Cho, Gee Young Suh, Jeong Hoon Yang
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Korean J Crit Care Med. 2014;29(1):52-56. Published online February 28, 2014
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DOI: https://doi.org/10.4266/kjccm.2014.29.1.52
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Abstract
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- Myocardial dysfunction can occur during severe sepsis and may accelerate in the condition of chronic decompensated heart failure. A 26-year-old female in remission from non-Hodgkin’s lymphoma presented with shock due to chronic heart failure combined with pneumonia. The patient was initially stabilized using a peripheral extracorporeal membrane oxygenator (ECMO) with antibiotics therapy, followed by left ventricular venting due to pulmonary edema that was complicated by left ventricular distension. Here, we report the successful application of ECMO to a patient with pneumonia underlying doxorubicin-induced cardiomyopathy. Although septic conditions remained unclear indication of ECMO, it might be considered a valuable therapeutic option in patients with chronic heart failure.
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